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SB366791
CAS No. 472981-92-3
SB366791( SB-366791 | SB 366791 | SB366791 )
Catalog No. M18586 CAS No. 472981-92-3
SB-366791 is a new and selective cinnamide TRPV1 antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 30 | In Stock |
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| 5MG | 41 | In Stock |
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| 10MG | 58 | In Stock |
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| 25MG | 122 | In Stock |
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| 50MG | 192 | In Stock |
|
| 100MG | 318 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSB366791
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NoteResearch use only, not for human use.
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Brief DescriptionSB-366791 is a new and selective cinnamide TRPV1 antagonist.
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DescriptionSB-366791is a potent and selective TRPV1 antagonist. SB-366791 inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation. SB-366791 decreased capsaicin-induced Ca2+ influx in cultured trigeminal ganglion cells in a concentration-dependent manner (0.5-10 microM) with an IC50 of 651.9 nM. SB366791 is a more selective and in vivo also a more potent TRPV1 receptor antagonist than capsazepine in the rat therefore, it may promote the assessment of the therapeutic utility of TRPV1 channel blockers.
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In Vitro——
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In VivoSB-366791 (30 μM) inhibits the frequency of miniature excitatory postsynaptic currents (EPSCs). SB-366791 (30 μM) reduces the frequency of spontaneous EPSCs in the spinal cord slices from FCA-treated rats. SB-366791(30 μM) inhibits the amplitude of C-fibre evoked EPSCs. SB-366791 has also been used in vivo to assess the potential analgesic action of the inhibition of TRPV1, and significantly inhibits capsaicin-induced hypothermia, eye wiping movements and vasodilatation in the knee joint. SB-366791 inhibits glutamatergic transmission via an apparently pre-synaptic mechanism(s).
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SynonymsSB-366791 | SB 366791 | SB366791
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PathwayOthers
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TargetOther Targets
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RecptorTRPV1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number472981-92-3
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Formula Weight287.74
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Molecular FormulaC16H14ClNO2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 39 mg/mL 135.54 mM; H2O : < 0.1 mg/mL
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SMILESCOC1=CC=CC(=C1)NC(=O)/C=C/C2=CC=C(C=C2)Cl
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Chemical Name3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gunthorpe MJ,et al. Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology. 2004 Jan;46(1):133-49.
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