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SB-225002
CAS No. 182498-32-4
SB-225002( SB225002 )
Catalog No. M12815 CAS No. 182498-32-4
A potent, selective non-peptide CXCR2 antagonist with IC50 of 22 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
|
| 10MG | 55 | In Stock |
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| 25MG | 116 | In Stock |
|
| 50MG | 213 | In Stock |
|
| 100MG | 383 | In Stock |
|
| 200MG | 584 | In Stock |
|
| 500MG | 888 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSB-225002
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective non-peptide CXCR2 antagonist with IC50 of 22 nM.
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DescriptionA potent, selective non-peptide CXCR2 antagonist with IC50 of 22 nM; displays >150-fold selectivity over CXCR1; potently inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROalpha in vitro; selectively blocks IL-8-induced neutrophil margination in rabbits.
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In Vitro——
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In Vivo——
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SynonymsSB225002
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorCXCR2
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number182498-32-4
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Formula Weight352.1402
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Molecular FormulaC13H10BrN3O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC1=CC=C([N+]([O-])=O)C=C1O)NC2=CC=CC=C2Br
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Chemical NameUrea, N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. White JR, et al. J Biol Chem. 1998 Apr 24;273(17):10095-8.
2. Auten RL, et al. J Pharmacol Exp Ther. 2001 Oct;299(1):90-5.
3. Manjavachi MN, et al. Eur J Pain. 2010 Jan;14(1):23-31.
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