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SAR-100842
CAS No. 1195941-38-8
SAR-100842( SAR100842 )
Catalog No. M10688 CAS No. 1195941-38-8
SAR-100842 (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 160 | In Stock |
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| 5MG | 259 | In Stock |
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| 10MG | 404 | In Stock |
|
| 25MG | 628 | In Stock |
|
| 50MG | 896 | In Stock |
|
| 100MG | 1197 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSAR-100842
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NoteResearch use only, not for human use.
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Brief DescriptionSAR-100842 (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays.
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DescriptionSAR-100842 (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays; demonstrates potential for the treatment of systemic sclerosis and related fibrotic diseases.Other Indication Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsSAR100842
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PathwayGPCR/G Protein
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TargetLysophospholipid Receptor
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RecptorEdg-2receptor
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number1195941-38-8
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Formula Weight445.515
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Molecular FormulaC27H27NO5
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Purity>98% (HPLC)
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SolubilityDMSO: Soluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C(C1(NC(C2=CC=C(OC)C(OCCC3=CC=CC(C)=C3)=C2)=O)CC4=C(C=CC=C4)C1)O
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Chemical Name2-{4-methoxy-3-[2-(3-methylphenyl)ethoxy]benzamido}-2,3-dihydro-1H-indene-2-carboxylic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ellery J, et al. Eur J Pharmacol. 2018 May 26;833:8-15.
2. Kihara Y, et al. Exp Cell Res. 2015 May 1;333(2):171-7.
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