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S29434

CAS No. 874484-20-5

S29434( —— )

Catalog No. M20697 CAS No. 874484-20-5

S29434 (NMDPEF) is a potent competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    S29434
  • Note
    Research use only, not for human use.
  • Brief Description
    S29434 (NMDPEF) is a potent competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).
  • Description
    S29434 (NMDPEF) is a potent competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).
  • In Vitro
    Cell Autophagy Assay Cell Line:HepG2 cell line Concentration:5 and 10 μM Incubation Time:24 hours Result:Mitochondrial ROS-independently and QR2-dependently triggered autophagy, and dose-dependently induced LC3-II which is a marker of autophagy vesicles.
  • In Vivo
    Animal Model:CH3 wild-type mice Dosage:1 and 15 mg/kg Administration:Intraperitoneal injection; 1 and 15 mg/kg once Result:Positively affected memory by inhibiting QR2.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NADPH
  • Recptor
    Quinone reductase 2(QR2)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    874484-20-5
  • Formula Weight
    374.39
  • Molecular Formula
    C21H18N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:12.5 mg/mL?(33.39 mM)
  • SMILES
    COc1ccc2n3Cc4cccnc4-c3c(CCNC(=O)c3ccco3)c2n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Boutin JA Bouillaud F Janda Eet al.S29434 a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization[J].Mol Pharmacol. 2019 Mar;95(3):269-285.
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