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S-Ruxolitinib
CAS No. 1160597-27-2
S-Ruxolitinib( —— )
Catalog No. M19421 CAS No. 1160597-27-2
Ruxolitinib (INCB018424) is the first potent selective JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameS-Ruxolitinib
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NoteResearch use only, not for human use.
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Brief DescriptionRuxolitinib (INCB018424) is the first potent selective JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays.
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DescriptionRuxolitinib (INCB018424) is the first potent selective JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays >130-fold selectivity for JAK1/2 versus JAK3.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetJAK
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RecptorJAK1| JAK2
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Research AreaCardiovascular Disease
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IndicationMyelofibrosis; Polycythaemia Vera
Chemical Information
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CAS Number1160597-27-2
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Formula Weight306.37
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Molecular FormulaC17H18N6
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Purity>98% (HPLC)
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SolubilityDMSO:61 mg/mL;Water:<1 mg/mL
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SMILESN#CCC(C1CCCC1)n2cc(cn2)c4ncnc3nccc34
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Chemical Name3-(4-(7H-Pyrrolo[23-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Quintas-Cardama A et al. Blood 2010 115(15) 3109-3117.
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