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Rineterkib

CAS No. 1715025-32-3

Rineterkib( LTT-462 | ERK-IN-1 )

Catalog No. M26206 CAS No. 1715025-32-3

Rineterkib is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 178 Get Quote
10MG 335 Get Quote
25MG 566 Get Quote
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Biological Information

  • Product Name
    Rineterkib
  • Note
    Research use only, not for human use.
  • Brief Description
    Rineterkib is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
  • Description
    Rineterkib is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.(In Vivo):In the Calu-6 human NSCLC subcutaneous tumor xenograft model, Rineterkib (50, 75 mg/kg, p.o.) treatment significantly reduces the tumor volume.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Calu-6 NSCLC xenograft tumor models in mice.Dosage:50, 75 mg/kg.Administration:Orally either daily (qd) or every other day (q2d) for 27 days.Result:Significantly reduced the tumor volume.
  • Synonyms
    LTT-462 | ERK-IN-1
  • Pathway
    Apoptosis
  • Target
    PERK
  • Recptor
    β-adrenoceptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1715025-32-3
  • Formula Weight
    578.434
  • Molecular Formula
    C26H27BrF3N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 200 mg/mL (345.77 mM)
  • SMILES
    CNC[C@@H](NC(=O)c1ccc(cc1F)-c1nc(cnc1N)[C@H]1CC[C@H](O)[C@@H](F)C1)c1cc(F)cc(Br)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cocker PJ, Lin MY, Tremblay M, Kaur S, Winstanley CA. The β-adrenoceptor blocker propranolol ameliorates compulsive-like gambling behaviour in a rodent slot machine task:implications for iatrogenic gambling disorder. Eur J Neurosci. 2018 Jul 17.
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