Ribocil( Ribocil )

Catalog No. M11578 CAS No. 1381289-58-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Ribocil
Note

Research use only, not for human use.
Brief Description

Ribocil is a synthetic mimic of riboflavin 5’-monophosphate (FMN) that competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB.
Description

Ribocil is a synthetic mimic of riboflavin 5’-monophosphate (FMN) that competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB; depletes cellular levels of riboflavin with an IC50 value of 0.3 μM and inhibits E. coli growth with an MIC value of 2 ug/ml.
In Vitro

——
In Vivo

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Synonyms

Ribocil
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

Infection
Indication

——

CAS Number

1381289-58-2
Formula Weight

382.4826
Molecular Formula

C19H22N6OS
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CNC1=NC=C(C=N1)CN2CCCC(C2)C3=NC(=CC(=O)N3)C4=CC=CS4
Chemical Name

4(3H)-Pyrimidinone, 2-[1-[[2-(methylamino)-5-pyrimidinyl]methyl]-3-piperidinyl]-6-(2-thienyl)-

1. Howe JA, et al. Nature. 2015 Oct 29;526(7575):672-7. 2. Hermann T. Nature. 2015 Oct 29;526(7575):650-1.

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