Remodelin

Research use only, not for human use.

A potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules.

A potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules; significantly reduces the prevalence of misshapen nuclei in HGPS cells, prevents FTI-induced nuclear shape defects in normal fibroblasts and U2OS cells; does not affect Golgi apparatus integrity or tubulin polymer assembly, and does not cause cells to accumulate in mitosis.

Cell Proliferation Assay Cell Line:Prostate cancer cell lines VCaP, PC3, and DU145Concentration:0,10,20,40 μM Incubation Time:1,2,7 days Result:Inhibited NAT10 and suppressed the growth of both AR-positive and AR-negative prostate cancer cells. Displayed significantly decreased cell proliferation activity over time, compared to the control group.Decreased colony formation ability with a dose-dependent manner. Immunofluorescence Cell Line:Prostate cancer cell lines VCaP, PC3, and DU145 Concentration:0,10,20,40 μM Incubation Time:24 hours Result:Showed a significant decrease in both the positive labeling rate and the fluorescence intensity compared to the control group. Significantly reduced both the staining foci of IdU and the staining foci of CldU compared to control group. Western Blot Analysis Cell Line:Skin fibroblasts from LmnaG609G/G609G and wildtype (WT) littermates Concentration:1 μM Incubation Time:7 days Result:Decreased the higher level of the DNA double-strand break (DSB) marker gamma H2AX (γH2AX, Ser-139 phosphorylated histone H2AX).

——

——

Cell Cycle/DNA Damage

HDAC

NAT10inhibitor

Other Indications

——

949912-58-7

282.3635

C15H14N4S

>98% (HPLC)

10 mM in DMSO

C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1

Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-

(-20℃)

With Ice Pack

≥ 2 years