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Relacorilant
CAS No. 1496510-51-0
Relacorilant( CORT 125134 )
Catalog No. M23647 CAS No. 1496510-51-0
Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 254 | In Stock |
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| 10MG | 403 | In Stock |
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| 25MG | 672 | In Stock |
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| 50MG | 945 | In Stock |
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| 100MG | 1278 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameRelacorilant
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NoteResearch use only, not for human use.
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Brief DescriptionRelacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor.
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DescriptionRelacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively). Relacorilant has the potential for Cushing’s syndrome treatment.
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In Vitro——
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In Vivo——
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SynonymsCORT 125134
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PathwayOthers
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TargetOther Targets
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RecptorGlucocorticoid receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1496510-51-0
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Formula Weight586.56
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Molecular FormulaC27H22F4N6O3S
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESCN1C=C(C=N1)S(=O)(=O)N2CCC3=CC4=C(C[C@@]3(C2)C(=O)C5=NC=CC(=C5)C(F)(F)F)C=NN4C6=CC=C(C=C6)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hunt HJ, et al. Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist. J Med Chem. 2017 Apr 27;60(8):3405-3421.
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