Cart
sales@molnova.com
Home - Products - Microbiology/Virology - HCV - Radalbuvir

Radalbuvir

CAS No. 1314795-11-3

Radalbuvir( GS 9669 )

Catalog No. M11266 CAS No. 1314795-11-3

Radalbuvir (GS-9669) is a highly optimized thumb site II nonnucleoside inhibitor of HCV NS5B polymerase with binding affinity of 1.35 nM for genotype 1b.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 1323 Get Quote
50MG 2682 Get Quote
100MG 3600 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Radalbuvir
  • Note
    Research use only, not for human use.
  • Brief Description
    Radalbuvir (GS-9669) is a highly optimized thumb site II nonnucleoside inhibitor of HCV NS5B polymerase with binding affinity of 1.35 nM for genotype 1b.
  • Description
    Radalbuvir (GS-9669) is a highly optimized thumb site II nonnucleoside inhibitor of HCV NS5B polymerase with binding affinity of 1.35 nM for genotype 1b; shows inhibition of WT genotype 1b replicon and NS5B M423T mutant replicon with EC50 of 6 nM and 12 nM respectively.
  • In Vitro
    Radalbuvir (GS-9669) shows high in vitro metabolic stability, long residence time in rats, and maintained high activity against the NS5B M423T mutation (GT1b M423T EC50 = 14 nM).
  • In Vivo
    ——
  • Synonyms
    GS 9669
  • Pathway
    Microbiology/Virology
  • Target
    HCV
  • Recptor
    HCV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1314795-11-3
  • Formula Weight
    543.719
  • Molecular Formula
    C30H41NO6S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=CCC(CC1)C(=O)N(C2CCC(CC2)(COC3CCOC3)O)C4=C(SC(=C4)C#CC(C)(C)C)C(=O)O
  • Chemical Name
    2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-((cis-4-hydroxy-4-((((3S)-tetrahydro-3-furanyl)oxy)methyl)cyclohexyl)(((1R)-4-methyl-3-cyclohexen-1-yl)carbonyl)amino)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lazerwith SE, et al. J Med Chem. 2014 Mar 13;57(5):1893-901. 2. Fenaux M, et al. Antimicrob Agents Chemother. 2013 Feb;57(2):804-10. 3. Dvory-Sobol H, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6599-606.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Narlaprevir

    A potent, second generation HCV NS3 serine protease inhibitor with Ki of 6 nM.

  • SB-734117

    SB-734117 inhibits productive replication of several HCMV strains. SB-734117 exhibited polypharmacology and was an inhibitor of several proteins from the AGC and CMCG kinase groups.

  • Glecaprevir

    Glecaprevir (ABT 493;A 1282576) is a novel HCV NS3/4A protease inhibitor with pan-genotypic activity, inhibits NS3/4A proteases from HCV genotypes 1-6 in vitro with IC50 of 3.5-11.3 nM.

Sign In Join Free