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RV-1729
CAS No. 1293915-42-0
RV-1729( RV1729 | RV 1729 )
Catalog No. M11188 CAS No. 1293915-42-0
RV-1729 is a potent, selective PI3Kδ inhibitor with IC50 of 12 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameRV-1729
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NoteResearch use only, not for human use.
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Brief DescriptionRV-1729 is a potent, selective PI3Kδ inhibitor with IC50 of 12 nM.
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DescriptionRV-1729 is a potent, selective PI3Kδ inhibitor with IC50 of 12 nM, 2-fold selectivity for PI3Kδ relative to PI3Kγ and 16-fold over PI3Kα; inhibits PMA-induced peroxide production in U937 cells and phosphorylation of Akt in MCP1-stimulated THP1 cells with IC50 of 1.1 and 46 nM; significantly inhibits allergen-induced responses in murine models of asthma and COPD.Asthma Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsRV1729 | RV 1729
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research AreaInflammation/Immunology
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IndicationAsthma
Chemical Information
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CAS Number1293915-42-0
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Formula Weight735.242
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Molecular FormulaC39H39ClN8O5
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N(CCOC)CCOC)CCCC#CC1=CC=CC(N=C(CN2N=C(C3=CC=CC(O)=C3)C4=C(N)N=CN=C42)N5CC6=CC=CC=C6Cl)=C1C5=O
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Chemical Name6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Norman P. Expert Opin Ther Pat. 2014 Apr;24(4):471-5.
2. Respivert Ltd. Crystalline PI3 kinase inhibitors. WO2013136076; 2013
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