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RRD-251
CAS No. 131916-62-6
RRD-251( RRD251 )
Catalog No. M11292 CAS No. 131916-62-6
RRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameRRD-251
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NoteResearch use only, not for human use.
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Brief DescriptionRRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM).
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DescriptionRRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM) but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding; inhibits Rb to recruit Raf-1 to proliferative promoters and inhibited E2F1-dependent transcriptional activity; inhibits anchorage-dependent and anchorage-independent growth of human cancer cells; significantly inhibits tumor growth in tumors with functional Rb in vivo.
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In Vitro——
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In Vivo——
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SynonymsRRD251
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PathwayMAPK/ERK Signaling
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TargetRaf
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RecptorRaf
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Research Area——
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Indication——
Chemical Information
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CAS Number131916-62-6
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Formula Weight235.126
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Molecular FormulaC8H8Cl2N2S
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC(=C(C=C1Cl)Cl)CSC(=N)N
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Chemical Name2,4-dichlorobenzyl carbamimidothioate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kinkade R, et al. Cancer Res. 2008 May 15;68(10):3810-8.
2. Singh S, et al. Mol Cancer Ther. 2010 Dec;9(12):3330-41.
3. Trevi?o JG, et al. Mol Cancer Ther. 2013 Dec;12(12):2722-34.
4. Wallace AS, et al. Oncotarget. 2016 Jul 19;7(29):46401-46418.
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RRD-251 hydrochlorid...
RRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM).
