RO5263397( —— )

Catalog No. M33107 CAS No. 1357266-05-7

RO5263397 is a TAAR1 specific agonist with oral activity that has been used in antidepressant studies.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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10MG	122	Get Quote
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500MG	1287	Get Quote
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Biological Information

Product Name

RO5263397
Note

Research use only, not for human use.
Brief Description

RO5263397 is a TAAR1 specific agonist with oral activity that has been used in antidepressant studies.
Description

RO5263397 is a potent, selective, and orally available TAAR1 agonist, with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition. Antidepressant-like effect.
In Vitro

——
In Vivo

Animal Model:Adult 4-5-month-old male WT littermates (C57BL/6 background) Dosage:0.1, 0.3, 1?mg/kg Administration:p.o.; dosing at the mid-light phase (ZT6)?Result:Increased wake time at 0.3 and 1?mg/kg
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

1357266-05-7
Formula Weight

194.21
Molecular Formula

C10H11FN2O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 260 mg/mL (1338.76 mM; Ultrasonic )
SMILES

Cc1c(F)cccc1[C@H]1COC(N)=N1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Galley G, et al. Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists.ACS Med Chem Lett.?2015 Dec 30;7(2):192-7.?

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