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RO-7

CAS No. 1370241-45-4

RO-7( RO7 )

Catalog No. M11524 CAS No. 1370241-45-4

RO-7 is a novel small molecule, broad-spectrum inhibitor of influenza acidic polymerase (PA) protein endonuclease activity with EC50 of 3.2-16 nM in MDCK cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RO-7
  • Note
    Research use only, not for human use.
  • Brief Description
    RO-7 is a novel small molecule, broad-spectrum inhibitor of influenza acidic polymerase (PA) protein endonuclease activity with EC50 of 3.2-16 nM in MDCK cells.
  • Description
    RO-7 is a novel small molecule, broad-spectrum inhibitor of influenza acidic polymerase (PA) protein endonuclease activity with EC50 of 3.2-16 nM in MDCK cells; inhibits transcription and genome replication steps in the influenza virus cycle, demonstrates activity against NAI-resistant and -susceptible seasonal influenza A and B viruses; also shows activity against avian-origin A(H5N1), A(H7N9), and A(H9N2) influenza viruses.
  • In Vitro
    RO-7 is a compound that potently inhibits influenza virus replication and belongs to a new class of drugs in late-stage clinical trials for treatment of influenza virus infection. RO-7 displays broad-spectrum anti-influenza activity in vitro and protects mice from lethal challenge with both influenza A and B viruses.
  • In Vivo
    RO-7 protects mice from lethal challenge with both influenza A and B viruses.
  • Synonyms
    RO7
  • Pathway
    Microbiology/Virology
  • Target
    Influenza Virus
  • Recptor
    Influenza Virus
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1370241-45-4
  • Formula Weight
    487.497
  • Molecular Formula
    C24H20F3N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1N([C@H](C)C(F)(F)F)CN([C@@H]2C3=CC=CC=C3SCC4=CC=CC=C24)N5C1=C(O)C(C=C5)=O
  • Chemical Name
    1-((S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-5-hydroxy-3-((R)-1,1,1-trifluoropropan-2-yl)-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jones JC, et al. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02460-16. 2. Jones JC, et al. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5504-14.
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