Cart
sales@molnova.com
RN-1734
CAS No. 946387-07-1
RN-1734( —— )
Catalog No. M20811 CAS No. 946387-07-1
RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM5.9 μM3.2 μM for hTRPV4 ?mTRPV4 and rTRPV4respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 30 | Get Quote |
|
| 5MG | 46 | Get Quote |
|
| 10MG | 67 | Get Quote |
|
| 25MG | 147 | Get Quote |
|
| 50MG | 249 | Get Quote |
|
| 100MG | 372 | Get Quote |
|
| 500MG | 843 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameRN-1734
-
NoteResearch use only, not for human use.
-
Brief DescriptionRN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM5.9 μM3.2 μM for hTRPV4 ?mTRPV4 and rTRPV4respectively).
-
DescriptionRN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM5.9 μM3.2 μM for hTRPV4 ?mTRPV4 and rTRPV4respectively).
-
In VitroApoptosis Analysis Cell Line: Microglial cells Concentration:27 hours Incubation Time:10μM Result:Significantly decreased the percentage of cleaved-caspase 3 positive cells.Western Blot Analysis Cell Line:Microglial cells Concentration:27 hours Incubation Time:10 μM esult:Alleviated CM (with LPS only)-induced decreases in CNP.
-
In VivoAnimal Model:CPZ-induced demyelination mouse model (C57BL/6 male mice)Dosage: 0.5 μl (10 μM in 5% DMSO and 0.9% NaCl)Administration:Microinjector pump for 5 weeks Result:Significantly reversed the decrease in CNP protein and improved myelination in CPZ-induced demyelination mouse.
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetTRP/TRPV Channel
-
RecptorhTRPV4
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number946387-07-1
-
Formula Weight353.31
-
Molecular FormulaC14H22Cl2N2O2S
-
Purity>98% (HPLC)
-
SolubilityDMSO:50 mg/mL (141.52 mM)
-
SMILESCC(C)NCCN(C(C)C)S(=O)(=O)c1ccc(Cl)cc1Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Meiying Liu Xuan et al. TRPV4 Inhibition Improved Myelination and Reduced Glia Reactivity and Inflammation in a Cuprizone-Induced Mouse Model of Demyelination.[J]. Frontiers in cellular neuroscience 2018.
molnova catalog
related products
-
AMG-333
AMG-333 (AMG333, AMG 333) is a novel potent, highly selective TRPM8 antagonist with IC50 of 13 nM and 20 nM for hTRPM8 and rTRPM8, respectively.
-
RN9893
RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.
-
Probenecid
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate.
