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RIPK2-IN-2
CAS No. 1581270-11-2
RIPK2-IN-2( RIPK2-IN-2 | RIPK2 IN 2 | RIPK2IN2 | RIPK2 inhibitor-2 | RIPK2 inhibitor 2 )
Catalog No. M12259 CAS No. 1581270-11-2
A potent, selective receptor interacting protein-2 (RIP2) kinase inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 312 | Get Quote |
|
| 50MG | 1341 | Get Quote |
|
| 100MG | 1791 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameRIPK2-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective receptor interacting protein-2 (RIP2) kinase inhibitor.
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DescriptionA potent, selective receptor interacting protein-2 (RIP2) kinase inhibitor.
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In VitroRIP2 kinase inhibitor 2 is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase is a TKL family serine/threonine protein kinase involved in innate immune signaling. Following activation, RIP2 kinase associates with NODI or NOD2 and appears to function principally as a molecular scaffold to bring together other kinases (TAK1, ΙΚΚα/β/γ) involved in NF-κΒ and mitogen-activated protein kinase activation.
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In Vivo——
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SynonymsRIPK2-IN-2 | RIPK2 IN 2 | RIPK2IN2 | RIPK2 inhibitor-2 | RIPK2 inhibitor 2
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PathwayApoptosis
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TargetRIP kinase
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RecptorRIP kinase
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1581270-11-2
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Formula Weight432.5364
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Molecular FormulaC21H28N4O4S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCOCCOC1=C(S(=O)(C(C)(C)C)=O)C=C2C(NC3=NNC(C)=C3C)=CC=NC2=C1
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Chemical Name4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-(2-methoxyethoxy)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Linda N. Casillas, et al. Amino-quinolines as kinase inhibitors. PCT Int. Appl. (2014), WO 2014043437 A1 20140320.
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