Quinidine

Research use only, not for human use.

Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent.?for the treatment of abnormal heart rhythms and also malaria.

Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent.?for the treatment of abnormal heart rhythms and also malaria.

Cell Cytotoxicity Assay Cell Line:MES-SA and MESSA/DX5 cells Concentration:10 μM Incubation Time:24 hours Result:Showed cytotoxicity against MES-SA cells in a concentration-dependent manner.Apoptosis Analysis Cell Line:MES-SA and MESSA/DX5 cells Concentration:10 μM Incubation Time:24 hours Result:Increased the apoptotic portion sub-G1 DNA contents induced by paclitaxel, while paclitaxel had no effect on sub-G1 DNA contents undergoing apoptosis.

Animal Model:Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5Dosage:10, 20, and 30 mg/kg Administration:Intraperitoneal injection; 10, 20, and 30 mg/kg; once Result:Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).

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Microbiology/Virology

Parasite

Parasite

Inflammation/Immunology

Nonalcoholic Steatohepatitis

56-54-2

324.42

C20H24N2O2

>98% (HPLC)

DMSO:50 mg/mL (154.12 mM)

C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12

(S)-[(2R4S5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol

(-20℃)

With Ice Pack

≥ 2 years