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Pyroxamide

CAS No. 382180-17-8

Pyroxamide( —— )

Catalog No. M20956 CAS No. 382180-17-8

Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Pyroxamide
  • Note
    Research use only, not for human use.
  • Brief Description
    Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM).
  • Description
    Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM).
  • In Vitro
    Cell Viability Assay Cell Line:RD cells; RH30B cells Concentration:1.25-20.0 μM Incubation Time:24 hours; 48 hours; 72 hours Result:Resulted in a cell growth decrease in RD and RH30B cells.Cell Cycle Analysis Cell Line:RD cells; RH30B cells Concentration:10.0 μM; 20.0 μM Incubation Time:48 hours Result:Increased the sub-G1?fractions at 48 hours compared with control samples.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    382180-17-8
  • Formula Weight
    265.31
  • Molecular Formula
    C13H19N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (471.15 mM)
  • SMILES
    O=C(CCCCCCC(=O)Nc1cccnc1)NO
  • Chemical Name
    N1-hydroxy-N8-(pyridin-3-yl)octanediamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Butler L M Webb Y Agus D B et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide an inhibitor of histone deacetylase[J]. Clinical Cancer Research 2001 7(4):962-970.
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