Cart
sales@molnova.com
Phox-I2
CAS No. 353495-22-4
Phox-I2( —— )
Catalog No. M34115 CAS No. 353495-22-4
Phox-I2 is an NOX2-specific inhibitor. Phox-I2 reverts ROS-accumulation and leads to refusion of mitochondrial networks.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 117 | Get Quote |
|
| 5MG | 188 | Get Quote |
|
| 10MG | 282 | Get Quote |
|
| 25MG | 453 | Get Quote |
|
| 50MG | 660 | Get Quote |
|
| 100MG | 889 | Get Quote |
|
| 500MG | 1782 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePhox-I2
-
NoteResearch use only, not for human use.
-
Brief DescriptionPhox-I2 is an NOX2-specific inhibitor. Phox-I2 reverts ROS-accumulation and leads to refusion of mitochondrial networks.
-
DescriptionPhox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetNADPH
-
RecptorNADPH-oxidase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number353495-22-4
-
Formula Weight337.33
-
Molecular FormulaC18H15N3O4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 250 mg/mL (741.11 mM; Ultrasonic )
-
SMILES[O-][N+](=O)c1cccc(c1)C1Nc2ccc(cc2C2C=CCC12)[N+]([O-])=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Emily E Bosco, et al. Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. Chem Biol. 2012 Feb 24;19(2):228-42.?
molnova catalog
related products
-
2-HBA
2-HBA a synthetic analog of curcumin is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
-
ML-090
ML-090 is NOX1-specific inhibitor(IC50 = 90 nM) which is >100 selectivity for NOX1 over NOX2, NOX3, NOX4 (all IC50s >10 μM).
-
AKR1C3-IN-4
AKR1C3-IN-4 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC 50 of 0.56 μM. AKR1C3-IN-4 has the potential for castrate resistant prostate cancer (CRPC) research.
