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Phenformin
CAS No. 114-86-3
Phenformin( —— )
Catalog No. M33658 CAS No. 114-86-3
Phenformin (BRN 1977317) is a biguanide compound with anticancer and anti-glycemic activity, inhibits skin tumor growth and promotes keratinocyte differentiation and apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 137 | In Stock |
|
| 50MG | 201 | In Stock |
|
| 100MG | 286 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePhenformin
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NoteResearch use only, not for human use.
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Brief DescriptionPhenformin (BRN 1977317) is a biguanide compound with anticancer and anti-glycemic activity, inhibits skin tumor growth and promotes keratinocyte differentiation and apoptosis.
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DescriptionPhenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number114-86-3
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Formula Weight205.26
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Molecular FormulaC10H15N5
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Purity>98% (HPLC)
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Solubility——
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SMILESNC(=N)NC(=N)NCCc1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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3'-Hydroxypterostilb...
3'-Hydroxypterostilbene a natural pterostilbene analogue effectively inhibits the growth of human colon cancer cells with IC50s of 9.0 40.2 and 70.9 μM for COLO 205 HCT-116 and HT-29 cells respectively by inducing apoptosis and autophagy.
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PBOX 6
PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound exhibiting anticancer and antitumor activity by inhibiting breast cancer cell growth in vitro and selectively inducing apoptosis in leukemia cells through c-Jun NH2 terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL.
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Bigelovin
Bigelovin is a selective retinoid X receptor α agonist.?Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a potent cytotoxic sesquiterpene lactone from Inula sp.
