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Perifosine
CAS No. 157716-52-4
Perifosine( KRX-0401 | NSC 639966 | D-21266 | KRX 0401 | KRX0401 | D21266 | D 21266 )
Catalog No. M12254 CAS No. 157716-52-4
A oral bioavailable alkylphospholipid that displays significant antiproliferative activity in vitro and in vivo in several human tumor model; acts as an Akt inhibitor and a PI3K inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 35 | In Stock |
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| 5MG | 57 | In Stock |
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| 10MG | 73 | In Stock |
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| 25MG | 147 | In Stock |
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| 50MG | 267 | In Stock |
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| 100MG | 421 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePerifosine
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NoteResearch use only, not for human use.
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Brief DescriptionA oral bioavailable alkylphospholipid that displays significant antiproliferative activity in vitro and in vivo in several human tumor model; acts as an Akt inhibitor and a PI3K inhibitor.
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DescriptionA oral bioavailable alkylphospholipid that displays significant antiproliferative activity in vitro and in vivo in several human tumor model; acts as an Akt inhibitor and a PI3K inhibitor, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway; enhances apoptosis and inhibits the growth of xenografts in nude mice combined with a lysosomal inhibitor.Brain Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsKRX-0401 | NSC 639966 | D-21266 | KRX 0401 | KRX0401 | D21266 | D 21266
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PathwayPI3K/Akt/mTOR signaling
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TargetAkt
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RecptorAkt
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Research AreaCancer
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IndicationBrain Cancer
Chemical Information
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CAS Number157716-52-4
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Formula Weight461.6584
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Molecular FormulaC25H52NO4P
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=P(OC1CC[N+](C)(C)CC1)([O-])OCCCCCCCCCCCCCCCCCC
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Chemical NamePiperidinium, 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-, inner salt
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kondapaka SB, et al. Mol Cancer Ther. 2003 Nov;2(11):1093-103.
2. Patel V, et al. Cancer Res. 2002 Mar 1;62(5):1401-9.
3. Becher OJ, et al. Cancer Res. 2010 Mar 15;70(6):2548-57.
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-
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