Thiamine levels in the blood of homozygous KO and KI mice feed a conventional diet are decreased to 0.058±0.051 and 0.126±0.092 μM, respectively.

1-Methylhydantoin is a small molecular weight polar substance the product of degradation of creatinine by bacteria. In mammals the metabolism of 1-methylhydantoin occurs via 5-hydroxy-1-methylhydantoin. In a reported human case 1-Methylhydantoin was found as an unexpected metabolite of the intelligence-affecting substance dupracetam.

Elgodipine significantly reduced the incidence and severity of exercise-induced angina pectoris systemically and was able to inhibit vascular smooth muscle proliferation through a mechanism independent of the expression of the transcription factors c-fos and c-jun.