Pam3CSK4

Research use only, not for human use.

Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.

Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.(In Vitro):Pam3CSK4 is a TLR1/2 heterodimer recognises triacylated lipopeptides. Pam3CSK4 (1 μg/mL) enhances the antibacterial functions of granulocyte macrophage-colony stimulating factor (GM-CSF) induced neutrophils to Methicillin-resistant Staphylococcus aureus.(In Vivo):Pam3CSK4 (5 mg/kg; i.p.; once a day for 9 days) alters brain, spleen and liver weights in neonatal mice.

Pam3CSK4 is a TLR1/2 heterodimer recognises triacylated lipopeptides.Pam3CSK4 (1 μg/mL) enhances the antibacterial functions of granulocyte macrophage-colony stimulating factor (GM-CSF) induced neutrophils to Methicillin-resistant Staphylococcus aureus.

Pam3CSK4 (5 mg/kg; i.p.; once a day for 9 days) alters brain, spleen and liver weights in neonatal mice. Animal Model:Time-mated pregnant C57BL/6 wild-type mice; B6.129-Tlr2tm1Kir/J (TLR2 -deficient) miceDosage:5 mg/kg Administration:Intraperitoneally (i.p.); once a day for 9 days Result:After repeated administration from postnatal day (PND3) to PND11, brain weight was decreased compared with endotoxin-free saline-treated animals at PND12. Decreased volume of cerebral gray matter, white matter in the forebrain and cerebellar molecular layer that was accompanied by an increase in spleen and liver weight at PND12.

Pam3Cys-Ser-(Lys)4

Immunology/Inflammation

TLR

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112208-00-1

1510.23

C81H156N10O13S

>98% (HPLC)

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Sequence:{Pam3Cys}-Ser-Lys-Lys-Lys-Lys

(-20℃)

With Ice Pack

≥ 2 years