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PTC725
CAS No. 1248581-07-8
PTC725( PTC 725 )
Catalog No. M11004 CAS No. 1248581-07-8
PTC725 is a potent, selective, and orally bioavailable inhibitor of HCV NS4B, inhibits HCV 1b (Con1) replicons with EC50 of 1.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1053 | Get Quote |
|
| 50MG | 2142 | Get Quote |
|
| 100MG | 2790 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePTC725
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NoteResearch use only, not for human use.
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Brief DescriptionPTC725 is a potent, selective, and orally bioavailable inhibitor of HCV NS4B, inhibits HCV 1b (Con1) replicons with EC50 of 1.7 nM.
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DescriptionPTC725 is a potent, selective, and orally bioavailable inhibitor of HCV NS4B, inhibits HCV 1b (Con1) replicons with EC50 of 1.7 nM; displays a selectivity index of >5,000 with respect to cellular GAPDH, and >1,000-fold selectivity window with respect to cytotoxicity; retains fully activity against HCV replicon mutants that are resistant to inhibitors of NS3 protease and NS5B polymerase, demonstrates synergistic affect in combination with alpha interferon in vivo.
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In Vitro——
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In Vivo——
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SynonymsPTC 725
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PathwayMicrobiology/Virology
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TargetHCV
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RecptorHCV
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Research Area——
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Indication——
Chemical Information
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CAS Number1248581-07-8
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Formula Weight518.491
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Molecular FormulaC23H18F4N6O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=S(C1=CC=C(C(N2C3=NC=CC=N3)=C(C#N)C4=C2C=C(CC)C(F)=C4)N=C1)(N[C@@H](C)C(F)(F)F)=O
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Chemical Name(S)-6-(3-Cyano-6-ethyl-5-fluoro-1-(pyrimidin-2-yl)-1H-indol-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyridine-3-sulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gu Z, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3250-61.
2. Zhang N, et al. J Med Chem. 2014 Mar 13;57(5):2121-35.
3. Graci JD, et al. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7060-7066.
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