PSI6206

Research use only, not for human use.

PSI-6206 (RO2433) is a selective HCV RNA polymerase inhibitor.

PSI-6206 (RO2433) is a selective HCV RNA polymerase inhibitor.

PSI-6206 (RO 2433) is tested for anti-HCV activity in both a cell-based quantitative real-time RT-PCR assay and surrogate bovine viral diarrhea virus (BVDV) assays. PSI-6206 demonstrates no activity or cytoxicity in any assay. The formation of the 5′-triphosphate (TP) of PSI-6130 (PSI-6130-TP) and RO2433 (RO2433-TP) increases with time and reached steady state levels at 48 h. RO2433-TP also inhibits RNA synthesis by the native HCV replicase isolated from HCV replicon cells and the recombinant HCV polymerase NS5B. PSI-6206 (RO2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase.

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GS-331007 | RO 2433

Microbiology/Virology

HCV

HCV replicon

Infection

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863329-66-2

260.22

C10H13FN2O5

>98% (HPLC)

DMSO: 10 mM

O=C1NC(C=CN1[C@@H]2O[C@H](CO)[C@@H](O)[C@]2(F)C)=O

1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-yl)pyrimidine-2,4-dione

(-20℃)

With Ice Pack

≥ 2 years