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PMEDAP

CAS No. 113852-41-8

PMEDAP( —— )

Catalog No. M28188 CAS No. 113852-41-8

PMEDAP is a potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality and an inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP also has anti-murine cytomegalovirus (MCMV) activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PMEDAP
  • Note
    Research use only, not for human use.
  • Brief Description
    PMEDAP is a potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality and an inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP also has anti-murine cytomegalovirus (MCMV) activity.
  • Description
    PMEDAP is a potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality and an inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP also has anti-murine cytomegalovirus (MCMV) activity.(In Vivo):In Three-week-old male NMRI mice inoculated with MSV, PMEDAP (0.25-5 mg/kg; IP; daily;) effected a significant delay in tumor appearance and an enhancement of the survival rate of tumor-bearing mice. PMEDAP also suppressed tumor formation and mortality in a dose-dependent manner.
  • In Vitro
    ——
  • In Vivo
    PMEDAP (0.25-5 mg/kg; IP; daily; starting on the day of MSV-infected and continuing for an additional four days) causes a dose-dependent suppression of tumor formation and mortality in newborn mice inoculated with MSV. Animal Model:Three-week-old male NMRI mice Dosage:0.25 mg/kg, 1 mg/kg, 5 mg/kg Administration:IP; daily; starting on the day of infection and continuing for an additional four days Result:Effected a significant delay in tumor appearance and an enhancement of the survival rate of tumor-bearing mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    113852-41-8
  • Formula Weight
    288.2
  • Molecular Formula
    C8H13N6O4P
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?0.1 M NaOH : 14.29 mg/mL (49.)
  • SMILES
    Nc1c2ncn(CCOCP(O)(O)=O)c2nc(N)n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Strupp C, Quesnot N, Richert L, Moore J, Bomann WH, Singh P. Weight of evidence and human relevance evaluation of the benfluralin mode of action in rodents (Part I): Liver carcinogenesis. Regul Toxicol Pharmacol. 2020 Nov;117:104758.
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