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PKUMDL-LC-101-D04

CAS No. 2143896-83-5

PKUMDL-LC-101-D04( —— )

Catalog No. M34896 CAS No. 2143896-83-5

PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PKUMDL-LC-101-D04
  • Note
    Research use only, not for human use.
  • Brief Description
    PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis.
  • Description
    PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a potent ferroptosis regulator glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GPX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2143896-83-5
  • Formula Weight
    378.94
  • Molecular Formula
    C14H23ClN4O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (659.74 mM; Ultrasonic )
  • SMILES
    Cl.NCCNS(=O)(=O)c1ccc(NC(=S)NC2CCCC2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li C, et al. Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4. J Med Chem. 2019;62(1):266-275. ?
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