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PIK-90

CAS No. 677338-12-4

PIK-90( PIK90 | PIK 90 )

Catalog No. M15589 CAS No. 677338-12-4

PIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PIK-90
  • Note
    Research use only, not for human use.
  • Brief Description
    PIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively.
  • Description
    PIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively; inhibits phosphorylation of Akt and S6, blocks the antiapoptotic protein Survivin and driving cell death in malignant glioma the clinical CDK1/2 inhibitor cooperated with roscovitine.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PIK90 | PIK 90
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    PI3Kα|PI3Kβ|PI3Kγ|PI3Kδ
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    677338-12-4
  • Formula Weight
    351.3593
  • Molecular Formula
    C18H17N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: < 1 mg/mL
  • SMILES
    O=C(NC1=NC2=C(C=CC(OC)=C2OC)C3=NCCN13)C4=CN=CC=C4
  • Chemical Name
    3-Pyridinecarboxamide, N-(2,3-dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fan QW, et al. Cancer Res. 2007 Sep 1;67(17):7960-5. 2. Niedermeier M, et al. Blood. 2009 May 28;113(22):5549-57. 3. Knight ZA, et al. Cell. 2006 May 19;125(4):733-47. 4. Cheng CK, et al. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12722-7.
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