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PI-828
CAS No. 942289-87-4
PI-828( —— )
Catalog No. M33466 CAS No. 942289-87-4
PI-828 is a phosphatidylinositol 3-kinase (PI3K) inhibitor, which is widely used to study the physiological function of PI3K and also promotes stem cell differentiation into mesoderm.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 70 | In Stock |
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| 5MG | 112 | In Stock |
|
| 10MG | 188 | In Stock |
|
| 25MG | 317 | In Stock |
|
| 50MG | 455 | In Stock |
|
| 100MG | 610 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePI-828
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NoteResearch use only, not for human use.
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Brief DescriptionPI-828 is a phosphatidylinositol 3-kinase (PI3K) inhibitor, which is widely used to study the physiological function of PI3K and also promotes stem cell differentiation into mesoderm.
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DescriptionPI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively.
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In VitroPI-828 (0.01-100 μM) exhibits cytotoxic effect on the 4T1 breast cancer cells and 4306 ovarian cancer cells. PI-828 (0.78-3.12 μM; 48 hours) decreases caspase 3 activation; higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis.Cell Viability Assay Cell Line:4T1 breast cancer cells and 4306 ovarian cancer cells Concentration:0.01, 0.1, 1, 10 and 100 μM Incubation Time:Result:Exhibited cytotoxic effect.Apoptosis Analysis Cell Line:Human embryonic carcinoma NCCIT cells Concentration: 0.78, 1.56, 3.12, 6.25, 12.5 μM Incubation Time:48 hours Result:Concentrations of ranging from 0.78 to 3.12 μM decreased caspase 3 activation; higher concentrations caused apoptosis.
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K | Casein Kinase
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Research Area——
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Indication——
Chemical Information
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CAS Number942289-87-4
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Formula Weight322.36
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Molecular FormulaC19H18N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 12.5 mg/mL (38.78 mM)
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SMILESNc1ccc(cc1)-c1cccc2c1oc(cc2=O)N1CCOCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gharbi SI, et al. Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J. 2007 May 15;404(1):15-21.?
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