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PHTPP
CAS No. 805239-56-9
PHTPP( PHTPP )
Catalog No. M16016 CAS No. 805239-56-9
A potent, selective antagonist of estrogen ERβ receptor; exhibits 36-fold selective for ERβ, and is fully effective as an ERα antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 34 | In Stock |
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| 5MG | 55 | In Stock |
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| 10MG | 84 | In Stock |
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| 25MG | 164 | In Stock |
|
| 50MG | 267 | In Stock |
|
| 100MG | 413 | In Stock |
|
| 500MG | 888 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePHTPP
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective antagonist of estrogen ERβ receptor; exhibits 36-fold selective for ERβ, and is fully effective as an ERα antagonist.
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DescriptionA potent, selective antagonist of estrogen ERβ receptor; exhibits 36-fold selective for ERβ, and is fully effective as an ERα antagonist, while exhibiting no significant agonism on ERβ or Erα; enhances SKOV3 and OV2008 ovarian cancer cell growth in in vitro assays.
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In VitroPHTPP is a selective ERβ antagonist. PHTPP reduces FSH-mediated cAMP production by 80% (p<0.01) while it has no effect on basal cAMP. PHTPP (10-6 M) inhibits E2-stimulated ERβ activity, but does not suppress E2-stimulated ERα activity. A high dose of PHTPP (10-6 M) slightly increases class 1 Igf1 mRNA expression, and facilitates the DPN-induced increase in class 1 Igf1 mRNA expression.
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In Vivo——
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SynonymsPHTPP
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorERβ
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number805239-56-9
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Formula Weight423.3
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Molecular FormulaC20H11F6N3O
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Purity>98% (HPLC)
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SolubilityDMSO: 14 mg/mL (33 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESOC1=CC=C(C2=C3N=C(C(F)(F)F)C=C(C(F)(F)F)N3N=C2C4=CC=CC=C4)C=C1
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Chemical Name4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Compton DR, et al. J Med Chem. 2004 Nov 18;47(24):5872-93.
2. Chan KK, et al. J Endocrinol. 2014 May 12;221(2):325-36.
3. Kajta M, et al. Neuroscience. 2013 May 15;238:345-60.
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