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PHI-101

CAS No. 2127107-15-5

PHI-101( —— )

Catalog No. M37298 CAS No. 2127107-15-5

PHI-101 is an orally available and selective checkpoint kinase 2 (Chk2) inhibitor for the study of refractory acute myelogenous leukemia (AML) and ovarian cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 278 Get Quote
5MG 436 Get Quote
10MG 702 Get Quote
25MG 1362 Get Quote
50MG 2190 Get Quote
100MG 3411 Get Quote
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Biological Information

  • Product Name
    PHI-101
  • Note
    Research use only, not for human use.
  • Brief Description
    PHI-101 is an orally available and selective checkpoint kinase 2 (Chk2) inhibitor for the study of refractory acute myelogenous leukemia (AML) and ovarian cancer.
  • Description
    PHI-101 is an orally active FLT3 inhibitor that overcomes resistance to multiple drug-resistant mutations. PHI-101 potently inhibits FLT3 single activating mutations (ITD or TKD mutants) and has inhibitory activity against FLT3 double (ITD/D835Y or ITD/F691L) and triple (ITD/D835Y/F691L) resistance mutations. PHI-101 has potential for research in relapsed or refractory acute myeloid leukemia (AML).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    Chk
  • Recptor
    Chk
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2127107-15-5
  • Formula Weight
    386.44
  • Molecular Formula
    C19H19FN4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (258.77 mM; Ultrasonic )
  • SMILES
    N(C(N)=O)C1=C(C(N[C@H]2CCCNC2)=O)SC(C#CC3=CC(F)=CC=C3)=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nam K Y, et al. PHI-101 Is a Potent Third-Generation FLT3 Inhibitor Developed to Overcome Resistance in Acute Myeloid Leukemia[J]. Blood, 2020, 136: 28.
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