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PGS-IN-1
CAS No. 102271-49-8
PGS-IN-1( KME-4 )
Catalog No. M26023 CAS No. 102271-49-8
PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 357 | In Stock |
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| 10MG | 530 | In Stock |
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| 25MG | 851 | In Stock |
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| 50MG | 1152 | In Stock |
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| 100MG | 1557 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePGS-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionPGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).
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DescriptionPGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).(In Vitro):PGS-IN-1 is the trans isomer of the synthesized α-benzulidene-γ-butyrolactone. PGS-IN-1 exhibits potent anti-inflammatory and PGS inhibitory activity with IC50 of 0.28 μM. PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase with IC50 of 1.05 μM.
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In VitroThe synthesized α-benzulidene-γ-butyrolactones are pure isomers (either cis or trans). PGS-IN-1 is the trans isomer. PGS-IN-1 exhibits potent antiinflammatrory and PGS inhibitory activity (IC50=0.28 μM). PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase (IC50=1.05 μM).
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In Vivo——
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SynonymsKME-4
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PathwayImmunology/Inflammation
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TargetLipoxygenase
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RecptorEGFR| IGF-1R
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Research Area——
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Indication——
Chemical Information
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CAS Number102271-49-8
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Formula Weight302.414
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Molecular FormulaC19H26O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)(C)c1cc(\C=C2/CCOC2=O)cc(c1O)C(C)(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.
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