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PF-543
CAS No. 1415562-82-1
PF-543( Sphingosine Kinase 1 Inhibitor II )
Catalog No. M18007 CAS No. 1415562-82-1
PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
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| 5MG | 70 | In Stock |
|
| 10MG | 104 | In Stock |
|
| 25MG | 196 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePF-543
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NoteResearch use only, not for human use.
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Brief DescriptionPF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
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DescriptionPF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
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In VitroWestern Blot Analysis Cell Line:Human pulmonary arterial smooth muscle (PASM) cells Concentration:10 nM, 100 nM, 1000 nM Incubation Time:24 ?hours Result:Abolished SK1 expression at nM concentrations.Apoptosis Analysis Cell Line:Human pulmonary arterial smooth muscle (PASM) cells Concentration:0.1 μM, 1 μM, 10 μM Incubation Time:24 ?hours Result:Induced caspase-3/7 activity in cultured human pulmonary smooth muscle cells.
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In VivoAnimal Model:Female C57BL/6 J mice (7-12 week-old) with hypoxic-induced pulmonary arterial hypertension Dosage:1 mg/kg Administration:Intraperitoneal injection; every second day; for 21 days Result:Reduced right ventricular hypertrophy. The protection involves a reduction in the expression of p53 (that promotes cardiomyocyte death) and an increase in the expression of anti-oxidant nuclear factor Nrf-2.
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SynonymsSphingosine Kinase 1 Inhibitor II
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PathwayOthers
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TargetOther Targets
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RecptorSphK1| SphK1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1415562-82-1
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Formula Weight465.6
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Molecular FormulaC27H31NO4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (214.78 mM)
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SMILESC(O)[C@@H]1N(CCC1)Cc1ccc(cc1)COc1cc(cc(c1)C)CS(=O)(=O)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Schnute ME, et al. Biochem J, 2012, 444(1), 79-88.
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