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PF-06426779
CAS No. 1817628-40-2
PF-06426779( PF06426779 )
Catalog No. M12792 CAS No. 1817628-40-2
PF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 628 | Get Quote |
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| 10MG | 1071 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePF-06426779
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NoteResearch use only, not for human use.
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Brief DescriptionPF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM.
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DescriptionPF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM; displays excellent selectivity against the human kinome, and >100-fold selectivity for IRAK4 over IRAK1.
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In VitroPF-06426779 inhibits IRAK4, with an IC50 of 12.7 nM in the peripheral blood mononuclear cells (PBMCs) assay.
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In Vivo——
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SynonymsPF06426779
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PathwayImmunology/Inflammation
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TargetIRAK
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RecptorIRAK
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Research Area——
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Indication——
Chemical Information
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CAS Number1817628-40-2
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Formula Weight347.346
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Molecular FormulaC17H18FN3O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (287.90 mM)
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SMILESCC1C(NC(=O)C1F)COC2=NC=CC3=CC(=C(C=C32)OC)C(=O)N
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Chemical Name1-(((2S,3S,4S)-4-Fluoro-3-methyl-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. De Nardo D, et al. J Biol Chem. 2018 Aug 3. pii: jbc.RA118.003314.
2. Lee KL, et al. J Med Chem. 2017 Jul 13;60(13):5521-5542.
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