Cart
sales@molnova.com
Home - Products - Endocrinology/Hormones - 5-HT Receptor - PF-04781340

PF-04781340

CAS No. 1648726-56-0

PF-04781340( PF 04781340 | PF04781340 )

Catalog No. M12519 CAS No. 1648726-56-0

A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 873 Get Quote
50MG 1782 Get Quote
100MG 2250 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PF-04781340
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability.
  • Description
    A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability; displays >150-fold selectivity over 5-HT2B receptors agonism (EC50=1484 nM); exhibits good metabolic stability in human liver microsomes (HLM) and moderate to good passive permeability in RRCK cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PF 04781340 | PF04781340
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1648726-56-0
  • Formula Weight
    267.376
  • Molecular Formula
    C17H21N3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    3-benzyl-N-methyl-6,7,8,9-tetrahydro-5H-pyrido[3,4-d]azepin-1-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • SHP099 hydrochloride

    SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor.

  • SB-357134

    A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5.

  • P-Hydroxyphenethyl t...

    P-Hydroxyphenethyl trans-ferulate exhibits affinity toward 5-HT(7) receptors in a competitive binding assay.

Sign In Join Free