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PF-04191834
CAS No. 1029317-21-2
PF-04191834( PF-4191834 )
Catalog No. M10139 CAS No. 1029317-21-2
PF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 72 | Get Quote |
|
| 10MG | 115 | Get Quote |
|
| 25MG | 237 | Get Quote |
|
| 50MG | 410 | Get Quote |
|
| 100MG | 605 | Get Quote |
|
| 500MG | 1287 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePF-04191834
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NoteResearch use only, not for human use.
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Brief DescriptionPF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM.
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DescriptionPF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM; displays 300‐fold over 12‐LO and 15‐LO, and no inhibition of the cyclooxygenase enzymes; is under clinical investigation for the oral treatment of asthma and pain.Pain Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsPF-4191834
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PathwayImmunology/Inflammation
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TargetLipoxygenase
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RecptorLipoxygenase
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number1029317-21-2
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Formula Weight393.502
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Molecular FormulaC22H23N3O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (254.13 mM)
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SMILESO=C(C1(C2=CC=CC(SC3=CC=C(C4=CC=NN4C)C=C3)=C2)CCOCC1)N
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Chemical Name4-(3-((4-(1-methyl-1H-pyrazol-5-yl)phenyl)thio)phenyl)tetrahydro-2H-pyran-4-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Masferrer JL, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):294-301.
2. Rzodkiewicz P, et al. Reumatologia. 2016;54(4):161-164. Epub 2016 Oct 5.
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