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Home - Products - Cell Cycle/DNA Damage - Potassium Channel - PD-118057

PD-118057

CAS No. 313674-97-4

PD-118057( PD 118057 | PD118057 )

Catalog No. M14010 CAS No. 313674-97-4

A potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PD-118057
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells.
  • Description
    A potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells; does not ot affect the voltage dependence and kinetics of gating parameters, and open conformation of the channel, also shows no major effect on I(Na), I(Ca,L), I(K1), and I(Ks); shortens the action potential duration and QT interval in arterially perfused rabbit ventricular wedge preparation, prevents action potential duration and QT prolongation caused by dofetilide at 3 uM.Heart Arrhythmia Discontinued.
  • In Vitro
    PD-118057 (3 μM and 10 μM) specifically increases hERG current and inhibits action potential duration in guinea pig ventricular muscle in acute isolation of guinea pig cardiomyocytes.PD-118057 (10 μM) reverses the current inhibition induced by Dof and Mox without changing the "hump" shape of IKr current recorded by action potential clamp, and only slightly increases the peak value of the suppressed current.
  • In Vivo
    ——
  • Synonyms
    PD 118057 | PD118057
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Cardiovascular Disease
  • Indication
    Heart Arrhythmia

Chemical Information

  • CAS Number
    313674-97-4
  • Formula Weight
    386.272
  • Molecular Formula
    C21H17Cl2NO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (258.89 mM)
  • SMILES
    O=C(O)C1=CC=CC=C1NC2=CC=C(CCC3=CC=C(Cl)C(Cl)=C3)C=C2
  • Chemical Name
    2-{4-[2-(3,4-dichloro-phenyl)-ethyl]-phenylamino}-benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhou J, et al. Mol Pharmacol. 2005 Sep;68(3):876-84. Epub 2005 Jun 23. 2. Patel C, et al. Heart Rhythm. 2008 Apr;5(4):585-90. 3. Perry M, et al. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20075-80.
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