P7C3-A20( —— )

Catalog No. M17211 CAS No. 1235481-90-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

P7C3-A20
Note

Research use only, not for human use.
Brief Description

P7C3 is a drug related to latrepirdine (dimebon), which has neuroprotective and proneurogenic effects, and may be potentially useful for the treatment of Alzheimer's disease and similar neurodegenerative disorders.
Description

P7C3 is a drug related to latrepirdine (dimebon), which has neuroprotective and proneurogenic effects, and may be potentially useful for the treatment of Alzheimer's disease and similar neurodegenerative disorders.
In Vitro

Cell Viability Assay Cell Line:PC12 cells Concentration:10?μM, 20 μM, 40?μM, 60 μM, 80?μM, 100 μM Incubation Time:8 hours Result:Alleviated oxygen-glucose deprivation (OGD)-induced cytotoxicity in PC12 cells. Apoptosis Analysis Cell Line:PC12 cells Concentration:40?μM, 60 μM, 80?μM, 100 μM Incubation Time:8 hours Result:Alleviated oxygen-glucose deprivation (OGD)-induced apoptosis in PC12 cells.
In Vivo

Animal Model:Sprague-Dawley rats (200-250 g) induced hypoxic-ischemic (HI) injury Dosage:5?mg/kg, 10?mg/kg Administration:Intraperitoneal injection; daily; for 7 days Result:Reduced infarct volume; reversed cell loss in the cortex and hippocampus and improved motor function without causing neurotoxicity.
Synonyms

——
Pathway

Tyrosine Kinase
Target

Src
Recptor

Others
Research Area

Neurological Disease
Indication

——

1. De Jesús-Cortés H, et al. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):17010-5.

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