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Oxychlororaphine
CAS No. 550-89-0
Oxychlororaphine( phenazine-1-carboxamide )
Catalog No. M28110 CAS No. 550-89-0
Oxychlororaphine inhibits strongly the growth of Streptomyces sp. 441.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 31 | In Stock |
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| 5MG | 50 | In Stock |
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| 10MG | 85 | In Stock |
|
| 25MG | 177 | In Stock |
|
| 50MG | 295 | In Stock |
|
| 100MG | 475 | In Stock |
|
| 500MG | 1071 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameOxychlororaphine
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NoteResearch use only, not for human use.
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Brief DescriptionOxychlororaphine inhibits strongly the growth of Streptomyces sp. 441.
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DescriptionOxychlororaphine inhibits strongly the growth of Streptomyces sp. 441.
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In VitroOxychloroaphine (1-256 μM; 24 h) has cytotoxicity with IC50 values for A549, HeLa, and SW480 cancer cell lines between 32 and 40 μM.Oxychloroaphine (1-150 μM; A549, HeLa, and SW480 cancer cell lines) causes cell membrane damage, leading to increase apoptosis and leakage of lactate dehydrogenase, and increases production of cytochrome c protein.Oxychloroaphine (32 μM; A549 and SW480 cells) induces cycle arrest at G1 phase and induction of sub-G phase.Oxychloroaphine (48 h; A549 cells) induces downregulation of antiapoptotic Bcl-2 protein and the activation of proapoptotic protein caspase-3 led to the cleavage of PARP. Cell Viability AssayCell Line:A549, HeLa, and SW480 cancer cell lines Concentration:1, 2, 4, 8, 16, 32, 64, 128, and 256 μM Incubation Time:24 hours Result:Inhibited cell proliferative in a dose-dependent manner.
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In Vivo——
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Synonymsphenazine-1-carboxamide
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorCarboxylesterase
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Research Area——
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Indication——
Chemical Information
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CAS Number550-89-0
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Formula Weight223.235
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Molecular FormulaC13H9N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (44.80 mM)
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SMILESNC(=O)c1cccc2nc3ccccc3nc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sztanke K. Synthesis of new derivatives of 8-aryl-3-phenyl-6,7-dihydro-4H-imidazo[2, 1-c][1,2,4]triazin-4-one. Acta Pol Pharm. 2004 Sep-Oct;61(5):373-7.
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