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Opaganib
CAS No. 915385-81-8
Opaganib( ABC294640 | ABC 294640 | ABC-294640 )
Catalog No. M16576 CAS No. 915385-81-8
Opaganib (ABC-294640, ABC294640) is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 113 | In Stock |
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| 25MG | 228 | In Stock |
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| 50MG | 393 | In Stock |
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| 100MG | 583 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameOpaganib
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NoteResearch use only, not for human use.
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Brief DescriptionOpaganib (ABC-294640, ABC294640) is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM.
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DescriptionOpaganib (ABC-294640, ABC294640) is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM; shows no activity against SphK-1 with IC50 of >100 uM; attenuates S1P formation in intact cells, suppresses the proliferation of a broad panel of tumor cell lines, and inhibits tumor cell migration concomitant with loss of microfilaments; demonstrates antitumor activity in adenocarcinoma xenograft models.Blood Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsABC294640 | ABC 294640 | ABC-294640
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PathwayImmunology/Inflammation
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TargetSphK
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RecptorSphK2
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number915385-81-8
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Formula Weight380.916
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Molecular FormulaC23H25ClN2O
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Purity>98% (HPLC)
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SolubilityDMSO: 71 mg/mL (186.4 mM); Ethanol: 27 mg/mL (70.9 mM); Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C([C@@]12C[C@]3(C4=CC=C(Cl)C=C4)C[C@@](C2)([H])C[C@](C3)([H])C1)NCC5=CC=NC=C5
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Chemical Name3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. French KJ, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):129-39.
2. Maines LW, et al. Inflammopharmacology. 2010 Apr;18(2):73-85.
3. Beljanski V, et al. J Pharmacol Exp Ther. 2010 May;333(2):454-64.
4. Antoon JW, et al. Endocrinology. 2010 Nov;151(11):5124-35.
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