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OP-1074
CAS No. ——
OP-1074( OP1074 )
Catalog No. M17021 CAS No. ——
OP-1074 (OP1074) is a potent, selective ER degrader (SERD), shows specific antiestrogenic activity for both ERα and Erβ.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameOP-1074
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NoteResearch use only, not for human use.
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Brief DescriptionOP-1074 (OP1074) is a potent, selective ER degrader (SERD), shows specific antiestrogenic activity for both ERα and Erβ.
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DescriptionOP-1074 (OP1074) is a potent, selective ER degrader (SERD), shows specific antiestrogenic activity for both ERα and ERβ, inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC50 of 1.6 and 3.2?nM, respectively; displays no activity on other steroid receptors; inhibits E2-induced proliferation of breast cells (MCF-7 cell IC50=7 nM) and degrades ERα, inhibiting ER-mediated signaling with IC50 of 3.2 nM; shrinks tumors in tamoxifen-resistant xenograft model.
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In Vitro——
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In Vivo——
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SynonymsOP1074
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorEstrogen Receptor/ERR
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight443.543
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Molecular FormulaC28H29NO4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-(((R)-3-methylpyrrolidin-1-yl)methoxy)phenyl)-2H-chromen-7-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fanning SW, et al. Nat Commun. 2018 Jun 18;9(1):2368.
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