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Nucleozin
CAS No. 341001-38-5
Nucleozin( Nucleozin )
Catalog No. M14155 CAS No. 341001-38-5
A small-molecule influenza A nucleoprotein (NP) inhibitor that triggers the aggregation of NP and inhibits its nuclear accumulation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
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| 5MG | 48 | In Stock |
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| 10MG | 77 | In Stock |
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| 25MG | 160 | In Stock |
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| 50MG | 260 | In Stock |
|
| 100MG | 385 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNucleozin
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NoteResearch use only, not for human use.
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Brief DescriptionA small-molecule influenza A nucleoprotein (NP) inhibitor that triggers the aggregation of NP and inhibits its nuclear accumulation.
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DescriptionA small-molecule influenza A nucleoprotein (NP) inhibitor that triggers the aggregation of NP and inhibits its nuclear accumulation; inhibits infection of MDCK cells by viruses influenza A/WSN/33, H3N2 (clinical isolate) and Vietnam/1194/04 (H5N1) with EC50 of 0.069 uM, 0.16 uM and 0.33 uM in PRA, respectively; protects mice challenged with lethal doses of avian influenza A H5N1; also targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection.Influenza Preclinical.
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In VitroNucleozin inhibits infection of MDCK cells by the viruses influenza A/WSN/33, H3N2 and Vietnam/1194/04 (H5N1) with an EC50 of 0.069 μM, 0.16 μM and 0.33 μM in plaque reduction assay (PRA) , respectively, severely suppresses viral growth at 0.1 μM and totally inhibites virus production at 1 μM in multicycle growth assays.
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In VivoNucleozin protectes mice challenged with lethal doses of avian influenza A H5N1.
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SynonymsNucleozin
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PathwayMicrobiology/Virology
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TargetInfluenza Virus
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RecptorInfluenza Virus
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Research AreaInfection
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IndicationInfluenza
Chemical Information
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CAS Number341001-38-5
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Formula Weight426.853
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Molecular FormulaC21H19ClN4O4
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Purity>98% (HPLC)
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SolubilityDMSO: 28.66 mg/mL (Need ultrasonic)
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SMILESO=C(N1CCN(C2=CC=C([N+]([O-])=O)C=C2Cl)CC1)C3=C(C)ON=C3C4=CC=CC=C4
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Chemical NameMethanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kao RY, et al. Nat Biotechnol. 2010 Jun;28(6):600-5.
2. Amorim MJ, et al. J Virol. 2013 Apr;87(8):4694-703.
3. Su CY, et al. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19151-6.
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