Nobiletin

Research use only, not for human use.

Nobiletin is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities.

Nobiletin has anti-inflammatory and anti-tumor invasion, proliferation, and metastasis activity in vitro and in animal studies. Nobiletin was also found to potentially inhibit cartilage degradation.

Western Blot Analysis Cell Line: U2OS and HOS cells Concentration:0 μM, 25 μM, 50 μM, 75 μM, 100 μM Incubation Time:24 hours Result:Progressively reduced protein expressions of MMP-2 and MMP-9. Considerably reduced the phosphorylation of p-IKKα/β and p-IκBα, and protein expression of NF-κB in the cell nuclear fraction with the concomitant increase of the NF-κB expression in the cytosolic fraction. Down-regulated the p-CREB and the SP-1 expressions in the nuclear fraction in U2OS and HOS cells.RT-PCR Cell Line: U2OS and HOS cells Concentration:0 μM, 25 μM, 50 μM, 75 μM, 100 μM Incubation Time:24 hours Result:Significantly reduced mRNA expressions of MMP-2 and MMP-9 dose-dependently in U2OS and HOS cells.

Animal Model:20- to 22-month-old male C57BL/6 mice Dosage:0.1% of regular diet Administration:Oral administration; daily; for 20 weeks Result:Fully restored glucose tolerance in aged mice, and increased basal body temperature and cold tolerance in aged mice. Led to a twofold increase in distance run/day on voluntary wheels compared with aged regular diet-fed mice during the active phase.

Nobiletin | Hexamethoxyflavone | NOB

Others

Other Targets

MMP

Cancer

——

478-01-3

402.4

C21H22O8

>98% (HPLC)

DMSO : ≥ 31 mg/mL; 77.04 mM

COc1c(cc(cc1)c1cc(=O)c2c(o1)c(c(c(c2OC)OC)OC)OC)OC

2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one

(-20℃)

With Ice Pack

≥ 2 years