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Nedometinib

CAS No. 2252314-46-6

Nedometinib( —— )

Catalog No. M37153 CAS No. 2252314-46-6

Nedometinib (NFX-179) is a selective mitogen-activated protein kinase kinase (MEK1) inhibitor with anticancer and antitumor activity, inhibits MAPK pathway signaling in the skin, inhibits the growth of human squamous cell lines in a dose-dependent manner, and can be used to study malignant tumors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 103 Get Quote
5MG 154 Get Quote
10MG 226 Get Quote
25MG 361 Get Quote
50MG 615 Get Quote
100MG 981 Get Quote
500MG Get Quote Get Quote
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Biological Information

  • Product Name
    Nedometinib
  • Note
    Research use only, not for human use.
  • Brief Description
    Nedometinib (NFX-179) is a selective mitogen-activated protein kinase kinase (MEK1) inhibitor with anticancer and antitumor activity, inhibits MAPK pathway signaling in the skin, inhibits the growth of human squamous cell lines in a dose-dependent manner, and can be used to study malignant tumors.
  • Description
    Nedometinib is a tyrosine kinase inhibitor targeting to MEK1. Nedometinib has antineoplastic effect and can be used for research in dermatosis, cutaneous fibroneuroma, neurofibromatosis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    MEK
  • Recptor
    MEK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2252314-46-6
  • Formula Weight
    470.24
  • Molecular Formula
    C17H16FIN4O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (212.66 mM; Ultrasonic )
  • SMILES
    O=C(NOCCO)C=1C=2C=CC=NC2N(C1NC3=CC=C(I)C=C3F)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kincaid, et al. Preparation of pyrrolopyridine-aniline compounds for treatment of dermal disorders. World Intellectual Property Organization, WO2018213810 A1. 2018-11-22.
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