NXL101( NXL 101 )

Catalog No. M16502 CAS No. 904302-98-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

NXL101
Note

Research use only, not for human use.
Brief Description

NXL101 is a novel quinoline bacterial DNA gyrase and topoisomerase IV inhibitor that shows potent activity against gram-positive bacteria.
Description

NXL101 is a novel quinoline bacterial DNA gyrase and topoisomerase IV inhibitor that shows potent activity against gram-positive bacteria, including methicillin- and fluoroquinolone-resistant strains; inhibits S. aureus DNA gyrase and topoisomerase IV with IC50 of 1.0 and 18 uM, respectively.Bacterial Infection Phase 1 Discontinued.
In Vitro

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In Vivo

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Synonyms

NXL 101
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

Infection
Indication

Bacterial Infection

CAS Number

904302-98-3
Formula Weight

504.635
Molecular Formula

C25H29FN2O4S2
Purity

>98% (HPLC)
Solubility

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SMILES

O=C([C@H]1CN(CCSC2=CC=CS2)CC[C@H]1CC[C@@H](C3=C(F)C=NC4=CC=C(OC)C=C34)O)O
Chemical Name

(3R,4R)-4-[(3S)-3-(3-Fluoro-6-methoxy-4-quinolinyl)-3-hydroxypropyl]-1-[2-(2-thienylthio)ethyl]-3-piperidinecarboxylic acid

1. Black MT, et al. Antimicrob Agents Chemother. 2008 Sep;52(9):3339-49.

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