NSC49652( —— )

Catalog No. M34352 CAS No. 908563-68-8

NSC49652 triggers apoptotic cell death dependent on p75NTR and JNK activity in neurons and melanoma cells, and inhibits tumor growth in a melanoma mouse model.

Purity : >98% (HPLC)

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2MG	47	Get Quote
5MG	68	Get Quote
10MG	116	Get Quote
25MG	227	Get Quote
50MG	361	Get Quote
100MG	530	Get Quote
500MG	1152	Get Quote
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Biological Information

Product Name

NSC49652
Note

Research use only, not for human use.
Brief Description

NSC49652 triggers apoptotic cell death dependent on p75NTR and JNK activity in neurons and melanoma cells, and inhibits tumor growth in a melanoma mouse model.
Description

NSC49652 is a reversible, orally active p75 neurotrophin receptor (p75NTR, also known as NGFR, TNFRSF16, and CD271) agonist. NSC49652 targets the transmembrane domain of p75NTR. NSC49652 induces apoptosis and affects the viability of melanoma cells.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis
Research Area

——
Indication

——

Chemical Information

CAS Number

908563-68-8
Formula Weight

225.24
Molecular Formula

C14H11NO2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 20.83 mg/mL (92.48 mM; )
SMILES

Oc1ccccc1C(=O)\C=C\c1cccnc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Goh ETH, et al. A Small Molecule Targeting the Transmembrane Domain of Death Receptor p75NTR Induces Melanoma Cell Death and Reduces Tumor Growth. Cell Chem Biol. 2018 Dec 20;25(12):1485-1494.e5.?

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