NS1643

Research use only, not for human use.

NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.

NS-1643 is a Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). NS1643 increased both steady-state and tail current at all voltages tested. The EC(50) value for HERG channel activation was 10.5 microM. HERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents an interesting new antiarrhythmic approach.

Western Blot Analysis Cell Line:MDA-MB-231, SKBR3 and MCF7 breast cancer cell lines Concentration:50 μM Incubation Time:24 h Result:Decreased Vimentin, N-cadherin and CD44 levels, and increased E-cadherin in breast cancer cell lines.

Animal Model:NSG mice with human-derived TNBC tumor xenografts Dosage:6 mg/kg Administration:Intraperitoneal injection; 6 mg/kg; twice per week Result:Significantly reduceed tumor .growth and the metastatic liver tumors were significantly smaller than those in the control group. Decreased levels of human nuclear antigen (HNA).

NS-1643 | NS 1643 | NS1643

Cell Cycle/DNA Damage

Rho

hERG

Others-Field

——

448895-37-2

380.24

C15H10F6N2O3

>98% (HPLC)

DMSO : ≥ 100 mg/mL; 262.99 mM

c1c(ccc(c1NC(=O)Nc1c(O)ccc(c1)C(F)(F)F)O)C(F)(F)F

1,3-bis(2-hydroxy-5-(trifluoromethyl)phenyl)urea

(-20℃)

With Ice Pack

≥ 2 years