NP10679

Research use only, not for human use.

NP10679 is an orally available, selective, brain-penetrating, potent, and pH-sensitive N-methyl-D-aspartate (NMDA) receptor inhibitor of the GluN2B subunit.

NP10679 is a selective, pH dependent GluN2B subunit-specific N-methyl-D-aspartate (NMDA) receptor inhibitor with high oral bioavailability and good brain penetration. NP10679 inhibits GluN2B with IC50s of 23 and 142 nM at pH 6.9 and 7.6, respectively. NP10679 is a histamine H1 antagonist and a hERG channel inhibitor with IC50s of 73 and 620 nM, respectively. NP10679 is a reversible inhibitor of human liver CYP enzymes.

——

Animal Model:Male C57BL/6 middle cerebral artery occlusion (MCAo) model of transient ischemia mice Dosage:2, 5 and 10 mg/kg Administration:Intraperitoneal injection; 2, 5 and 10 mg/kg, 15 minutes prior to transient ischemia Result:Dose-dependently reduced infarct volumes with an ED50 of 1 mg/kg.

——

Angiogenesis

HER/HSP

HER | P450 | Histamine Receptor | NMDAR

——

——

2914889-88-4

449.47

C23H26F3N3O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (222.48 mM; Ultrasonic )

O(C[C@@H](CN1CCN(CC1)C2=CC=C(C(F)(F)F)C=C2)O)C=3C=C4C(=CC3)NC(=O)CC4

——

(-20℃)

With Ice Pack

≥ 2 years