Cart
sales@molnova.com
NKP-608
CAS No. 177707-12-9
NKP-608( NK 608 | NK608 )
Catalog No. M12675 CAS No. 177707-12-9
A non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 233 | Get Quote |
|
| 50MG | 896 | Get Quote |
|
| 100MG | 1422 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameNKP-608
-
NoteResearch use only, not for human use.
-
Brief DescriptionA non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM.
-
DescriptionA non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM; exhibits an anxiolytic-like effect in the social interaction and social exploration test in rats; orally active.Irritable Bowel Syndrome Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsNK 608 | NK608
-
PathwayGPCR/G Protein
-
TargetNeurokinin Receptor
-
RecptorNeurokinin Receptor
-
Research AreaOther Indications
-
IndicationIrritable Bowel Syndrome
Chemical Information
-
CAS Number177707-12-9
-
Formula Weight619.9846
-
Molecular FormulaC31H24ClF6N3O2
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=C(C1=CC=NC2=CC=CC=C12)N[C@@H]3C[C@@H](CC4=CC=C(Cl)C=C4)N(C(C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O)CC3
-
Chemical Name4-Quinolinecarboxamide, N-[(2R,4S)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-[(4-chlorophenyl)methyl]-4-piperidinyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Gentsch C, et al. Behav Brain Res. 2002 Jul 18;133(2):363-8.
2. Vassout A, et al. Regul Pept. 2000 Dec 22;96(1-2):7-16.
3. Coulson FR, et al. Inflamm Res. 2002 Jul;51(7):317-23.
molnova catalog
related products
-
Elinzanetant
Elinzanetant is a dual antagonist of neurokinin (NK) receptors 1 and 3 and modulates reproductive hormone secretion.
-
Substance P (1-9)
Substance P (1-9) is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder. Subtance P is responsible for a number of excitatory effects on both central and peripheral neurons.
-
Hemokinin 1 (mouse)
Hemokinin 1 (mouse) is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor.
