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NITD-304

CAS No. 1473450-60-0

NITD-304( NITD304 )

Catalog No. M12025 CAS No. 1473450-60-0

NITD-304 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 15 nM against M tuberculosis H37Rv.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NITD-304
  • Note
    Research use only, not for human use.
  • Brief Description
    NITD-304 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 15 nM against M tuberculosis H37Rv.
  • Description
    NITD-304 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 15 nM against M tuberculosis H37Rv; shows potent activity against both drug-sensitive and multidrug-resistant clinical isolates of Mtb; demonstrates effectivity in treating both acute and chronic Mtb infections in mouse efficacy models.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NITD304
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1473450-60-0
  • Formula Weight
    339.27
  • Molecular Formula
    C17H20Cl2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C(N1)=CC2=C1C=C(Cl)C=C2Cl)NC3CCC(C)(C)CC3
  • Chemical Name
    4,6-dichloro-N-(4,4-dimethylcyclohexyl)-1H-indole-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rao SP, et al. Sci Transl Med. 2013 Dec 4;5(214):214ra168.
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